Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621161
Title:
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.
Authors:
Prajeeth, Chittappen K; Kronisch, Julius; Khorooshi, Reza; Knier, Benjamin; Toft-Hansen, Henrik; Gudi, Viktoria; Floess, Stefan; Huehn, Jochen; Owens, Trevor; Korn, Thomas; Stangel, Martin
Abstract:
Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. 2017, 14 (1):204 J Neuroinflammation
Journal:
Journal of neuroinflammation
Issue Date:
16-Oct-2017
URI:
http://hdl.handle.net/10033/621161
DOI:
10.1186/s12974-017-0978-3
PubMed ID:
29037246
Type:
Article
Language:
en
ISSN:
1742-2094
Appears in Collections:
publications of the division experimentelle Immunologie (EXIM)

Full metadata record

DC FieldValue Language
dc.contributor.authorPrajeeth, Chittappen Ken
dc.contributor.authorKronisch, Juliusen
dc.contributor.authorKhorooshi, Rezaen
dc.contributor.authorKnier, Benjaminen
dc.contributor.authorToft-Hansen, Henriken
dc.contributor.authorGudi, Viktoriaen
dc.contributor.authorFloess, Stefanen
dc.contributor.authorHuehn, Jochenen
dc.contributor.authorOwens, Trevoren
dc.contributor.authorKorn, Thomasen
dc.contributor.authorStangel, Martinen
dc.date.accessioned2017-11-06T14:31:09Z-
dc.date.available2017-11-06T14:31:09Z-
dc.date.issued2017-10-16-
dc.identifier.citationEffectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. 2017, 14 (1):204 J Neuroinflammationen
dc.identifier.issn1742-2094-
dc.identifier.pmid29037246-
dc.identifier.doi10.1186/s12974-017-0978-3-
dc.identifier.urihttp://hdl.handle.net/10033/621161-
dc.description.abstractAutoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuroinflammation. Previously, we have shown that only Th1 but not Th17 effectors activate microglia. However, it is not clear which cells are targets of Th17 effectors in the CNS.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleEffectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalJournal of neuroinflammationen

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