Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621171
Title:
Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.
Authors:
Monjas, Leticia; Swier, Lotteke J Y M; Setyawati, Inda; Slotboom, Dirk J; Hirsch, Anna K H
Abstract:
We applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target.
Affiliation:
Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus E9.1, 66123 Saarbrücken, Germany.
Citation:
Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine. 2017, 12 (20):1693-1696 ChemMedChem
Journal:
ChemMedChem
Issue Date:
20-Oct-2017
URI:
http://hdl.handle.net/10033/621171
DOI:
10.1002/cmdc.201700440
PubMed ID:
28960943
Type:
Article
Language:
en
ISSN:
1860-7187
Appears in Collections:
publications of the department drug design and optimization (HIPS]DDOP)

Full metadata record

DC FieldValue Language
dc.contributor.authorMonjas, Leticiaen
dc.contributor.authorSwier, Lotteke J Y Men
dc.contributor.authorSetyawati, Indaen
dc.contributor.authorSlotboom, Dirk Jen
dc.contributor.authorHirsch, Anna K Hen
dc.date.accessioned2017-11-08T13:08:39Z-
dc.date.available2017-11-08T13:08:39Z-
dc.date.issued2017-10-20-
dc.identifier.citationDynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine. 2017, 12 (20):1693-1696 ChemMedChemen
dc.identifier.issn1860-7187-
dc.identifier.pmid28960943-
dc.identifier.doi10.1002/cmdc.201700440-
dc.identifier.urihttp://hdl.handle.net/10033/621171-
dc.description.abstractWe applied dynamic combinatorial chemistry (DCC) to identify ligands of ThiT, the S-component of the energy-coupling factor (ECF) transporter for thiamine in Lactococcus lactis. We used a pre-equilibrated dynamic combinatorial library (DCL) and saturation-transfer difference (STD) NMR spectroscopy to identify ligands of ThiT. This is the first report in which DCC is used for fragment growing to an ill-defined pocket, and one of the first reports for its application with an integral membrane protein as target.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshATP-Binding Cassette Transportersen
dc.subject.meshBacterial Proteinsen
dc.subject.meshBiological Transporten
dc.subject.meshCarrier Proteinsen
dc.subject.meshCombinatorial Chemistry Techniquesen
dc.subject.meshDrug Designen
dc.subject.meshLactococcus lactisen
dc.subject.meshModels, Molecularen
dc.subject.meshMolecular Structureen
dc.subject.meshProtein Subunitsen
dc.subject.meshSmall Molecule Librariesen
dc.subject.meshThiamineen
dc.titleDynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus E9.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalChemMedChemen

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