Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621183
Title:
Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility.
Authors:
Andrade, Diego Fontana de; Vukosavljevic, Branko; Benvenutti, Edilson Valmir; Pohlmann, Adriana Raffin; Guterres, Sílvia Stanisçuaski; Windbergs, Maike; Beck, Ruy Carlos Ruver
Abstract:
This study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant. Dynamic light scattering, turbidimetry, determination of surface area and pore size distribution, electron microscopy and confocal Raman microscopy (CRM) were used to characterize the proposed system and to better understand the differences in the redispersion behavior. An easily aqueous redispersion of the spray-dried powder composed of maltodextrin and L-leucine (90:10 w/w) was obtained, depending on the particle number density. Their surface area decreased in the presence of LNC. CRM enabled the visualization of the spatial distribution of the different compounds in the powders affording to better understand the influence of the particle number density of the fed sample on their redispersion behavior. This study shows the need for optimizing initial particle number density in the liquid formulation to develop redispersible spray-dried LNC powders.
Affiliation:
Helmholtz-Institut für pharmazeitische Forschung Saarland, Universitäzscampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Redispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility. 2017:1-12 Pharm Dev Technol
Journal:
Pharmaceutical development and technology
Issue Date:
20-Nov-2017
URI:
http://hdl.handle.net/10033/621183
DOI:
10.1080/10837450.2017.1400559
PubMed ID:
29095657
Type:
Article
Language:
en
ISSN:
1097-9867
Appears in Collections:
publications of the department drug delivery ([TC] DDEL)

Full metadata record

DC FieldValue Language
dc.contributor.authorAndrade, Diego Fontana deen
dc.contributor.authorVukosavljevic, Brankoen
dc.contributor.authorBenvenutti, Edilson Valmiren
dc.contributor.authorPohlmann, Adriana Raffinen
dc.contributor.authorGuterres, Sílvia Stanisçuaskien
dc.contributor.authorWindbergs, Maikeen
dc.contributor.authorBeck, Ruy Carlos Ruveren
dc.date.accessioned2017-11-22T15:15:25Z-
dc.date.available2017-11-22T15:15:25Z-
dc.date.issued2017-11-20-
dc.identifier.citationRedispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility. 2017:1-12 Pharm Dev Technolen
dc.identifier.issn1097-9867-
dc.identifier.pmid29095657-
dc.identifier.doi10.1080/10837450.2017.1400559-
dc.identifier.urihttp://hdl.handle.net/10033/621183-
dc.description.abstractThis study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant. Dynamic light scattering, turbidimetry, determination of surface area and pore size distribution, electron microscopy and confocal Raman microscopy (CRM) were used to characterize the proposed system and to better understand the differences in the redispersion behavior. An easily aqueous redispersion of the spray-dried powder composed of maltodextrin and L-leucine (90:10 w/w) was obtained, depending on the particle number density. Their surface area decreased in the presence of LNC. CRM enabled the visualization of the spatial distribution of the different compounds in the powders affording to better understand the influence of the particle number density of the fed sample on their redispersion behavior. This study shows the need for optimizing initial particle number density in the liquid formulation to develop redispersible spray-dried LNC powders.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleRedispersible spray-dried lipid-core nanocapsules intended for oral delivery: the influence of the particle number on redispersibility.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Institut für pharmazeitische Forschung Saarland, Universitäzscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalPharmaceutical development and technologyen

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