The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621196
Title:
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.
Authors:
He, Jin-Shu; Meyer-Hermann, Michael; Xiangying, Deng; Zuan, Lim Yok; Jones, Leigh Ann; Ramakrishna, Lakshmi; de Vries, Victor C; Dolpady, Jayashree; Aina, Hoi; Joseph, Sabrina; Narayanan, Sriram; Subramaniam, Sharrada; Puthia, Manoj; Wong, Glenn; Xiong, Huizhong; Poidinger, Michael; Urban, Joseph F; Lafaille, Juan J; Curotto de Lafaille, Maria A
Abstract:
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.
Affiliation:
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7, 30625 Hannover, Germany.
Citation:
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. 2013, 210 (12):2755-71 J. Exp. Med.
Journal:
The Journal of experimental medicine
Issue Date:
18-Nov-2013
URI:
http://hdl.handle.net/10033/621196
DOI:
10.1084/jem.20131539
PubMed ID:
24218137
Type:
Article
Language:
en
ISSN:
1540-9538
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorHe, Jin-Shuen
dc.contributor.authorMeyer-Hermann, Michaelen
dc.contributor.authorXiangying, Dengen
dc.contributor.authorZuan, Lim Yoken
dc.contributor.authorJones, Leigh Annen
dc.contributor.authorRamakrishna, Lakshmien
dc.contributor.authorde Vries, Victor Cen
dc.contributor.authorDolpady, Jayashreeen
dc.contributor.authorAina, Hoien
dc.contributor.authorJoseph, Sabrinaen
dc.contributor.authorNarayanan, Sriramen
dc.contributor.authorSubramaniam, Sharradaen
dc.contributor.authorPuthia, Manojen
dc.contributor.authorWong, Glennen
dc.contributor.authorXiong, Huizhongen
dc.contributor.authorPoidinger, Michaelen
dc.contributor.authorUrban, Joseph Fen
dc.contributor.authorLafaille, Juan Jen
dc.contributor.authorCurotto de Lafaille, Maria Aen
dc.date.accessioned2017-12-05T13:23:11Z-
dc.date.available2017-12-05T13:23:11Z-
dc.date.issued2013-11-18-
dc.identifier.citationThe distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. 2013, 210 (12):2755-71 J. Exp. Med.en
dc.identifier.issn1540-9538-
dc.identifier.pmid24218137-
dc.identifier.doi10.1084/jem.20131539-
dc.identifier.urihttp://hdl.handle.net/10033/621196-
dc.description.abstractThe mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshApoptosisen
dc.subject.meshB-Lymphocytesen
dc.subject.meshCell Differentiationen
dc.subject.meshGerminal Centeren
dc.subject.meshGreen Fluorescent Proteinsen
dc.subject.meshImmunoglobulin Class Switchingen
dc.subject.meshImmunoglobulin Een
dc.subject.meshImmunoglobulin Gen
dc.subject.meshImmunologic Memoryen
dc.subject.meshMiceen
dc.subject.meshMice, Inbred BALB Cen
dc.subject.meshMice, Transgenicen
dc.subject.meshModels, Immunologicalen
dc.subject.meshNippostrongylusen
dc.subject.meshPlasma Cellsen
dc.subject.meshReceptors, Antigen, B-Cellen
dc.subject.meshSignal Transductionen
dc.subject.meshStrongylida Infectionsen
dc.titleThe distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH, Feodor-Lynen-Str.7, 30625 Hannover, Germany.en
dc.identifier.journalThe Journal of experimental medicineen

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