2.50
Hdl Handle:
http://hdl.handle.net/10033/621212
Title:
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.
Authors:
Wagner, Stefanie; Hauck, Dirk; Hoffmann, Michael; Sommer, Roman; Joachim, Ines; Müller, Rolf ( 0000-0002-1042-5665 ) ; Imberty, Anne; Varrot, Annabelle; Titz, Alexander ( 0000-0001-7408-5084 )
Abstract:
Biofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.
Affiliation:
HIPS, Helmholtz-Institut für pharmazeutische Forchung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.
Citation:
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. 2017 Angew. Chem. Int. Ed. Engl.
Journal:
Angewandte Chemie (International ed. in English)
Issue Date:
28-Sep-2017
URI:
http://hdl.handle.net/10033/621212
DOI:
10.1002/anie.201709368
PubMed ID:
28960731
Type:
Article
Language:
en
ISSN:
1521-3773
Appears in Collections:
publications of the junior research group chemical biology of carbohydrates ([HIPS]CBCH); publications of the department of microbial natural substances ([HIPS]MINS)

Full metadata record

DC FieldValue Language
dc.contributor.authorWagner, Stefanieen
dc.contributor.authorHauck, Dirken
dc.contributor.authorHoffmann, Michaelen
dc.contributor.authorSommer, Romanen
dc.contributor.authorJoachim, Inesen
dc.contributor.authorMüller, Rolfen
dc.contributor.authorImberty, Anneen
dc.contributor.authorVarrot, Annabelleen
dc.contributor.authorTitz, Alexanderen
dc.date.accessioned2017-12-20T10:44:14Z-
dc.date.available2017-12-20T10:44:14Z-
dc.date.issued2017-09-28-
dc.identifier.citationCovalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. 2017 Angew. Chem. Int. Ed. Engl.en
dc.identifier.issn1521-3773-
dc.identifier.pmid28960731-
dc.identifier.doi10.1002/anie.201709368-
dc.identifier.urihttp://hdl.handle.net/10033/621212-
dc.description.abstractBiofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleCovalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.en
dc.typeArticleen
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forchung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalAngewandte Chemie (International ed. in English)en

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