2.50
Hdl Handle:
http://hdl.handle.net/10033/621227
Title:
The biology and mathematical modelling of glioma invasion: a review.
Authors:
Alfonso, J C L ( 0000-0002-9005-6897 ) ; Talkenberger, K; Seifert, M; Klink, B; Hawkins-Daarud, A; Swanson, K R; Hatzikirou, H; Deutsch, A
Abstract:
Adult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low- to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.
Affiliation:
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.
Citation:
The biology and mathematical modelling of glioma invasion: a review. 2017, 14 (136) J R Soc Interface
Journal:
Journal of the Royal Society, Interface
Issue Date:
Nov-2017
URI:
http://hdl.handle.net/10033/621227
DOI:
10.1098/rsif.2017.0490
PubMed ID:
29118112
PubMed Central ID:
5721156
Additional Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721156/
Type:
Article
Language:
en
ISSN:
1742-5662
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorAlfonso, J C Len
dc.contributor.authorTalkenberger, Ken
dc.contributor.authorSeifert, Men
dc.contributor.authorKlink, Ben
dc.contributor.authorHawkins-Daarud, Aen
dc.contributor.authorSwanson, K Ren
dc.contributor.authorHatzikirou, Hen
dc.contributor.authorDeutsch, Aen
dc.date.accessioned2018-01-09T11:59:13Z-
dc.date.available2018-01-09T11:59:13Z-
dc.date.issued2017-11-
dc.identifier.citationThe biology and mathematical modelling of glioma invasion: a review. 2017, 14 (136) J R Soc Interfaceen
dc.identifier.issn1742-5662-
dc.identifier.pmid29118112-
dc.identifier.doi10.1098/rsif.2017.0490-
dc.identifier.urihttp://hdl.handle.net/10033/621227-
dc.description.abstractAdult gliomas are aggressive brain tumours associated with low patient survival rates and limited life expectancy. The most important hallmark of this type of tumour is its invasive behaviour, characterized by a markedly phenotypic plasticity, infiltrative tumour morphologies and the ability of malignant progression from low- to high-grade tumour types. Indeed, the widespread infiltration of healthy brain tissue by glioma cells is largely responsible for poor prognosis and the difficulty of finding curative therapies. Meanwhile, mathematical models have been established to analyse potential mechanisms of glioma invasion. In this review, we start with a brief introduction to current biological knowledge about glioma invasion, and then critically review and highlight future challenges for mathematical models of glioma invasion.en
dc.language.isoenen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721156/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleThe biology and mathematical modelling of glioma invasion: a review.en
dc.typeArticleen
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.en
dc.identifier.journalJournal of the Royal Society, Interfaceen
dc.identifier.pmcid5721156-

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