2.50
Hdl Handle:
http://hdl.handle.net/10033/621233
Title:
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.
Authors:
Lucas, Sébastien; Omata, Yasunori; Hofmann, Jörg; Böttcher, Martin; Iljazovic, Aida; Sarter, Kerstin; Albrecht, Olivia; Schulz, Oscar; Krishnacoumar, Brenda; Krönke, Gerhard; Herrmann, Martin; Mougiakakos, Dimitrios; Strowig, Till; Schett, Georg; Zaiss, Mario M
Abstract:
Microbial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents postmenopausal and inflammation-induced bone loss. The protective effects of SCFA on bone mass are associated with inhibition of osteoclast differentiation and bone resorption in vitro and in vivo, while bone formation is not affected. Mechanistically, propionate (C3) and butyrate (C4) induce metabolic reprogramming of osteoclasts resulting in enhanced glycolysis at the expense of oxidative phosphorylation, thereby downregulating essential osteoclast genes such as TRAF6 and NFATc1. In summary, these data identify SCFA as potent regulators of osteoclast metabolism and bone homeostasis.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. 2018, 9 (1):55 Nat Commun
Journal:
Nature communications
Issue Date:
2018
URI:
http://hdl.handle.net/10033/621233
DOI:
10.1038/s41467-017-02490-4
PubMed ID:
29302038
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
publications of the research group microbial immune regulation (MIKI)

Full metadata record

DC FieldValue Language
dc.contributor.authorLucas, Sébastienen
dc.contributor.authorOmata, Yasunorien
dc.contributor.authorHofmann, Jörgen
dc.contributor.authorBöttcher, Martinen
dc.contributor.authorIljazovic, Aidaen
dc.contributor.authorSarter, Kerstinen
dc.contributor.authorAlbrecht, Oliviaen
dc.contributor.authorSchulz, Oscaren
dc.contributor.authorKrishnacoumar, Brendaen
dc.contributor.authorKrönke, Gerharden
dc.contributor.authorHerrmann, Martinen
dc.contributor.authorMougiakakos, Dimitriosen
dc.contributor.authorStrowig, Tillen
dc.contributor.authorSchett, Georgen
dc.contributor.authorZaiss, Mario Men
dc.date.accessioned2018-01-16T08:49:05Z-
dc.date.available2018-01-16T08:49:05Z-
dc.date.issued2018-
dc.identifier.citationShort-chain fatty acids regulate systemic bone mass and protect from pathological bone loss. 2018, 9 (1):55 Nat Communen
dc.identifier.issn2041-1723-
dc.identifier.pmid29302038-
dc.identifier.doi10.1038/s41467-017-02490-4-
dc.identifier.urihttp://hdl.handle.net/10033/621233-
dc.description.abstractMicrobial metabolites are known to modulate immune responses of the host. The main metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain fatty acids (SCFA), affect local and systemic immune functions. Here we show that SCFA are regulators of osteoclast metabolism and bone mass in vivo. Treatment of mice with SCFA as well as feeding with a high-fiber diet significantly increases bone mass and prevents postmenopausal and inflammation-induced bone loss. The protective effects of SCFA on bone mass are associated with inhibition of osteoclast differentiation and bone resorption in vitro and in vivo, while bone formation is not affected. Mechanistically, propionate (C3) and butyrate (C4) induce metabolic reprogramming of osteoclasts resulting in enhanced glycolysis at the expense of oxidative phosphorylation, thereby downregulating essential osteoclast genes such as TRAF6 and NFATc1. In summary, these data identify SCFA as potent regulators of osteoclast metabolism and bone homeostasis.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleShort-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalNature communicationsen

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