Aethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621288
Title:
Aethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica.
Authors:
Chepkirui, Clara; Sum, Winnie C; Cheng, Tian; Matasyoh, Josphat C; Decock, Cony; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
A mycelial culture of the Kenyan basidiomyceteFomitiporia aethiopicawas fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes1-5, for which we propose the trivial name aethiopinolones A-E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Aethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica. 2018, 23 (2) Molecules
Journal:
Molecules (Basel, Switzerland)
Issue Date:
9-Feb-2018
URI:
http://hdl.handle.net/10033/621288
DOI:
10.3390/molecules23020369
PubMed ID:
29425150
Type:
Article
Language:
en
ISSN:
1420-3049
Appears in Collections:
publications of the department of microbial drugs (MWIS)

Full metadata record

DC FieldValue Language
dc.contributor.authorChepkirui, Claraen
dc.contributor.authorSum, Winnie Cen
dc.contributor.authorCheng, Tianen
dc.contributor.authorMatasyoh, Josphat Cen
dc.contributor.authorDecock, Conyen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2018-02-20T15:16:34Z-
dc.date.available2018-02-20T15:16:34Z-
dc.date.issued2018-02-09-
dc.identifier.citationAethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica. 2018, 23 (2) Moleculesen
dc.identifier.issn1420-3049-
dc.identifier.pmid29425150-
dc.identifier.doi10.3390/molecules23020369-
dc.identifier.urihttp://hdl.handle.net/10033/621288-
dc.description.abstractA mycelial culture of the Kenyan basidiomyceteFomitiporia aethiopicawas fermented on rice and the cultures were extracted with methanol. Subsequent HPLC profiling and preparative chromatography of its crude extract led to the isolation of five previously undescribed pregnenolone type triterpenes1-5, for which we propose the trivial name aethiopinolones A-E. The chemical structures of the aethiopinolones were determined by extensive 1D- and 2D-NMR, and HRMS data analysis. The compounds exhibited moderate cytotoxic effects against various human cancer cell lines, but they were found devoid of significant nematicidal and antimicrobial activities.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleAethiopinolones A-E, New Pregnenolone Type Steroids from the East African Basidiomycete Fomitiporia aethiopica.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecules (Basel, Switzerland)en

Related articles on PubMed

This item is licensed under a Creative Commons License
Creative Commons
All Items in HZI are protected by copyright, with all rights reserved, unless otherwise indicated.