2.50
Hdl Handle:
http://hdl.handle.net/10033/621306
Title:
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.
Authors:
Hoffmann, Thomas; Krug, Daniel; Bozkurt, Nisa; Duddela, Srikanth; Jansen, Rolf; Garcia, Ronald; Gerth, Klaus; Steinmetz, Heinrich; Müller, Rolf ( 0000-0002-1042-5665 )
Abstract:
Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus. In addition, we report the discovery and structure elucidation of rowithocin, a myxobacterial secondary metabolite featuring an uncommon phosphorylated polyketide scaffold.
Affiliation:
HIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.
Citation:
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria. 2018, 9 (1):803 Nat Commun
Journal:
Nature communications
Issue Date:
23-Feb-2018
URI:
http://hdl.handle.net/10033/621306
DOI:
10.1038/s41467-018-03184-1
PubMed ID:
29476047
Type:
Article
Language:
en
ISSN:
2041-1723
Appears in Collections:
publications of the department of microbial natural substances ([HIPS]MINS)

Full metadata record

DC FieldValue Language
dc.contributor.authorHoffmann, Thomasen
dc.contributor.authorKrug, Danielen
dc.contributor.authorBozkurt, Nisaen
dc.contributor.authorDuddela, Srikanthen
dc.contributor.authorJansen, Rolfen
dc.contributor.authorGarcia, Ronalden
dc.contributor.authorGerth, Klausen
dc.contributor.authorSteinmetz, Heinrichen
dc.contributor.authorMüller, Rolfen
dc.date.accessioned2018-03-06T14:03:22Z-
dc.date.available2018-03-06T14:03:22Z-
dc.date.issued2018-02-23-
dc.identifier.citationCorrelating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria. 2018, 9 (1):803 Nat Communen
dc.identifier.issn2041-1723-
dc.identifier.pmid29476047-
dc.identifier.doi10.1038/s41467-018-03184-1-
dc.identifier.urihttp://hdl.handle.net/10033/621306-
dc.description.abstractSome bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus. In addition, we report the discovery and structure elucidation of rowithocin, a myxobacterial secondary metabolite featuring an uncommon phosphorylated polyketide scaffold.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleCorrelating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.en
dc.typeArticleen
dc.contributor.departmentHIPS, Helmholtz-Institut für pharmazeutische Forschung Saarland, Universitätscampus 8.1, 66123 Saarbrücken, Germany.en
dc.identifier.journalNature communicationsen
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