A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621315
Title:
A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.
Authors:
Zhang, Jing-Jing; Muenzner, Julienne K; Abu El Maaty, Mohamed A; Karge, Bianka; Schobert, Rainer; Wölfl, Stefan; Ott, Ingo
Abstract:
A rhodium(i) and a ruthenium(ii) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(ii) complex was largely inactive, the rhodium(i) NHC complex displayed selective cytotoxicity and significant anti-metastatic and in vivo anti-vascular activities and acted as both a mammalian and an E. coli thioredoxin reductase inhibitor. In HCT-116 cells it increased the reactive oxygen species level, leading to DNA damage, and it induced cell cycle arrest, decreased the mitochondrial membrane potential, and triggered apoptosis. This rhodium(i) NHC derivative thus represents a multi-target compound with promising anti-cancer potential.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
A multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action. 2016, 45 (33):13161-8 Dalton Trans
Journal:
Dalton transactions (Cambridge, England : 2003)
Issue Date:
16-Aug-2016
URI:
http://hdl.handle.net/10033/621315
DOI:
10.1039/c6dt02025a
PubMed ID:
27334935
Type:
Article
Language:
en
ISSN:
1477-9234
Appears in Collections:
Publications of the research group Chemical Biology (CBIO)

Full metadata record

DC FieldValue Language
dc.contributor.authorZhang, Jing-Jingen
dc.contributor.authorMuenzner, Julienne Ken
dc.contributor.authorAbu El Maaty, Mohamed Aen
dc.contributor.authorKarge, Biankaen
dc.contributor.authorSchobert, Raineren
dc.contributor.authorWölfl, Stefanen
dc.contributor.authorOtt, Ingoen
dc.date.accessioned2018-03-08T10:20:32Z-
dc.date.available2018-03-08T10:20:32Z-
dc.date.issued2016-08-16-
dc.identifier.citationA multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action. 2016, 45 (33):13161-8 Dalton Transen
dc.identifier.issn1477-9234-
dc.identifier.pmid27334935-
dc.identifier.doi10.1039/c6dt02025a-
dc.identifier.urihttp://hdl.handle.net/10033/621315-
dc.description.abstractA rhodium(i) and a ruthenium(ii) complex with a caffeine derived N-heterocyclic carbene (NHC) ligand were biologically investigated as organometallic conjugates consisting of a metal center and a naturally occurring moiety. While the ruthenium(ii) complex was largely inactive, the rhodium(i) NHC complex displayed selective cytotoxicity and significant anti-metastatic and in vivo anti-vascular activities and acted as both a mammalian and an E. coli thioredoxin reductase inhibitor. In HCT-116 cells it increased the reactive oxygen species level, leading to DNA damage, and it induced cell cycle arrest, decreased the mitochondrial membrane potential, and triggered apoptosis. This rhodium(i) NHC derivative thus represents a multi-target compound with promising anti-cancer potential.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshAnimalsen
dc.subject.meshApoptosisen
dc.subject.meshBacteriaen
dc.subject.meshCaffeineen
dc.subject.meshCell Cycleen
dc.subject.meshCell Line, Tumoren
dc.subject.meshCell Survivalen
dc.subject.meshChick Embryoen
dc.subject.meshChorioallantoic Membraneen
dc.subject.meshCoordination Complexesen
dc.subject.meshDNA Damageen
dc.subject.meshHumansen
dc.subject.meshMembrane Potential, Mitochondrialen
dc.subject.meshMethaneen
dc.subject.meshReactive Oxygen Speciesen
dc.subject.meshRhodiumen
dc.subject.meshWound Healingen
dc.titleA multi-target caffeine derived rhodium(i) N-heterocyclic carbene complex: evaluation of the mechanism of action.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalDalton transactions (Cambridge, England : 2003)en

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