Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621322
Title:
Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.
Authors:
Binder, Sebastian C; Meyer-Hermann, Michael ( 0000-0002-4300-2474 )
Abstract:
Intravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells.
Affiliation:
BRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.
Citation:
Implications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division. 2016, 7:593 Front Immunol
Journal:
Frontiers in immunology
Issue Date:
2016
URI:
http://hdl.handle.net/10033/621322
DOI:
10.3389/fimmu.2016.00593
PubMed ID:
28066409
Type:
Article
Language:
en
ISSN:
1664-3224
Appears in Collections:
publications of the research group system immunology ([BRICS]SIMM)

Full metadata record

DC FieldValue Language
dc.contributor.authorBinder, Sebastian Cen
dc.contributor.authorMeyer-Hermann, Michaelen
dc.date.accessioned2018-03-14T10:27:20Z-
dc.date.available2018-03-14T10:27:20Z-
dc.date.issued2016-
dc.identifier.citationImplications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division. 2016, 7:593 Front Immunolen
dc.identifier.issn1664-3224-
dc.identifier.pmid28066409-
dc.identifier.doi10.3389/fimmu.2016.00593-
dc.identifier.urihttp://hdl.handle.net/10033/621322-
dc.description.abstractIntravital imaging of antibody optimization in germinal center (GC) reactions has set a new dimension in the understanding of the humoral immune response during the last decade. The inclusion of spatio-temporal cellular dynamics in the research on GCs required analysis using the agent-based mathematical models. In this study, we integrate the available intravital imaging data from various research groups and incorporate these into a quantitative mathematical model of GC reactions and antibody affinity maturation. Interestingly, the integration of data concerning the spatial organization of GCs and B cell motility allows to draw conclusions on the strength of the selection pressure and the control of B cell division by T follicular helper cells.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleImplications of Intravital Imaging of Murine Germinal Centers on the Control of B Cell Selection and Division.en
dc.typeArticleen
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56, 38106 Braunschweig, Germany.en
dc.identifier.journalFrontiers in immunologyen

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