Members of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in Streptococcus pyogenes.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621327
Title:
Members of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in Streptococcus pyogenes.
Authors:
Babbar, Anshu; Kumar, Venkatesan Naveen; Bergmann, René; Barrantes, Israel; Pieper, Dietmar H; Itzek, Andreas; Nitsche-Schmitz, D Patric
Abstract:
Conventionally categorized as commensals, the Streptococci of the species S. anginosus are facultative human pathogens that are difficult to diagnose and often overlooked. Furthermore, detailed investigation and diagnosis of S. anginosus infections is hampered by unexplored taxonomy and widely elusive molecular pathogenesis. To explore their pathogenic potential, S. anginosus isolates collected from patients of two geographical locations (Vellore, India and Leipzig, Germany) were subjected to multi-locus sequence analysis (MLSA). This analysis revealed the potential presence of a new distinct clade of the species S. anginosus, tentatively termed here as genomosubspecies vellorensis. A complementary PCR-based screening for S. pyogenes virulence factor as well as antibiotic resistance genes revealed not only the presence of superantigen- and extracellular DNase coding genes identical to corresponding genes of S. pyogenes, but also of erythromycin and tetracycline resistance genes in the genomes of the analyzed S. anginosus isolates, thus posing a matter of significant health concern. Identification of new pathogenic S. anginosus strains capable of causing difficult to treat infections may pose additional challenges to the diagnosis and treatment of Streptococcus based infections.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Members of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in Streptococcus pyogenes. 2017, 307 (3):174-181 Int. J. Med. Microbiol.
Journal:
International journal of medical microbiology : IJMM
Issue Date:
Apr-2017
URI:
http://hdl.handle.net/10033/621327
DOI:
10.1016/j.ijmm.2017.02.002
PubMed ID:
28274699
Type:
Article
Language:
en
ISSN:
1618-0607
Appears in Collections:
publications of the research group microbial interactions and processes (MINP)

Full metadata record

DC FieldValue Language
dc.contributor.authorBabbar, Anshuen
dc.contributor.authorKumar, Venkatesan Naveenen
dc.contributor.authorBergmann, Renéen
dc.contributor.authorBarrantes, Israelen
dc.contributor.authorPieper, Dietmar Hen
dc.contributor.authorItzek, Andreasen
dc.contributor.authorNitsche-Schmitz, D Patricen
dc.date.accessioned2018-03-20T10:22:31Z-
dc.date.available2018-03-20T10:22:31Z-
dc.date.issued2017-04-
dc.identifier.citationMembers of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in Streptococcus pyogenes. 2017, 307 (3):174-181 Int. J. Med. Microbiol.en
dc.identifier.issn1618-0607-
dc.identifier.pmid28274699-
dc.identifier.doi10.1016/j.ijmm.2017.02.002-
dc.identifier.urihttp://hdl.handle.net/10033/621327-
dc.description.abstractConventionally categorized as commensals, the Streptococci of the species S. anginosus are facultative human pathogens that are difficult to diagnose and often overlooked. Furthermore, detailed investigation and diagnosis of S. anginosus infections is hampered by unexplored taxonomy and widely elusive molecular pathogenesis. To explore their pathogenic potential, S. anginosus isolates collected from patients of two geographical locations (Vellore, India and Leipzig, Germany) were subjected to multi-locus sequence analysis (MLSA). This analysis revealed the potential presence of a new distinct clade of the species S. anginosus, tentatively termed here as genomosubspecies vellorensis. A complementary PCR-based screening for S. pyogenes virulence factor as well as antibiotic resistance genes revealed not only the presence of superantigen- and extracellular DNase coding genes identical to corresponding genes of S. pyogenes, but also of erythromycin and tetracycline resistance genes in the genomes of the analyzed S. anginosus isolates, thus posing a matter of significant health concern. Identification of new pathogenic S. anginosus strains capable of causing difficult to treat infections may pose additional challenges to the diagnosis and treatment of Streptococcus based infections.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject.meshDeoxyribonucleasesen
dc.subject.meshDrug Resistance, Bacterialen
dc.subject.meshGenotypeen
dc.subject.meshGermanyen
dc.subject.meshHumansen
dc.subject.meshIndiaen
dc.subject.meshMultilocus Sequence Typingen
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshStreptococcal Infectionsen
dc.subject.meshStreptococcus anginosusen
dc.subject.meshStreptococcus pyogenesen
dc.subject.meshSuperantigensen
dc.subject.meshVirulence Factorsen
dc.titleMembers of a new subgroup of Streptococcus anginosus harbor virulence related genes previously observed in Streptococcus pyogenes.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalInternational journal of medical microbiology : IJMMen

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