2.50
Hdl Handle:
http://hdl.handle.net/10033/621329
Title:
Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola.
Authors:
Mulwa, Lucky S ( 0000-0002-9365-8834 ) ; Jansen, Rolf ( 0000-0002-3592-4807 ) ; Praditya, Dimas F; Mohr, Kathrin I; Wink, Joachim; Steinmann, Eike; Stadler, Marc ( 0000-0002-7284-8671 )
Abstract:
Two new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacteriumLabilithrixluteola(DSM 27648T). Additionally, four metabolites3,4,5and6already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal ¹H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound3had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Six Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. 2018, 23 (3) Molecules
Journal:
Molecules (Basel, Switzerland)
Issue Date:
28-Feb-2018
URI:
http://hdl.handle.net/10033/621329
DOI:
10.3390/molecules23030542
PubMed ID:
29495640
Type:
Article
Language:
en
ISSN:
1420-3049
Appears in Collections:
publications of the department of microbial drugs (MWIS); publications of the research group microbial strain collection (MISG); publications of the research group virus transmission ([TC]VIRT)

Full metadata record

DC FieldValue Language
dc.contributor.authorMulwa, Lucky Sen
dc.contributor.authorJansen, Rolfen
dc.contributor.authorPraditya, Dimas Fen
dc.contributor.authorMohr, Kathrin Ien
dc.contributor.authorWink, Joachimen
dc.contributor.authorSteinmann, Eikeen
dc.contributor.authorStadler, Marcen
dc.date.accessioned2018-03-21T15:35:12Z-
dc.date.available2018-03-21T15:35:12Z-
dc.date.issued2018-02-28-
dc.identifier.citationSix Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola. 2018, 23 (3) Moleculesen
dc.identifier.issn1420-3049-
dc.identifier.pmid29495640-
dc.identifier.doi10.3390/molecules23030542-
dc.identifier.urihttp://hdl.handle.net/10033/621329-
dc.description.abstractTwo new secondary metabolites, labindole A [2-methyl-3-(2-nitroethyl)-3H-indole] (1) and labindole B [2-methyl-3-(2-nitrovinyl)-3H-indole] (2), were isolated from the myxobacteriumLabilithrixluteola(DSM 27648T). Additionally, four metabolites3,4,5and6already known from other sources were obtained. Their structures were elucidated from high resolution electrospray ionisation mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectroscopy data and their relative configuration was assigned based on nuclear Overhauser effect (NOE) and vicinal ¹H-NMR coupling data. The compounds where tested for biological activities; labindoles A (1) and B (2) exhibited significant activity against Hepatitis C Virus, 9H-carbazole (3), 3-chloro-9H-carbazole (4) and 4-hydroxymethyl-quinoline (5) showed antifungal activities. Moreover, compound3had weak to moderate antibacterial activities, while labindoles A (1) and B (2) were devoid of significant antifungal and antibacterial effects.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleSix Heterocyclic Metabolites from the Myxobacterium Labilithrix luteola.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalMolecules (Basel, Switzerland)en

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