2.50
Hdl Handle:
http://hdl.handle.net/10033/621337
Title:
Biochemistry of proinflammatory macrophage activation.
Authors:
Nonnenmacher, Yannic; Hiller, Karsten
Abstract:
In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.
Affiliation:
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Citation:
Biochemistry of proinflammatory macrophage activation. 2018 Cell. Mol. Life Sci.
Journal:
Cellular and molecular life sciences : CMLS
Issue Date:
3-Mar-2018
URI:
http://hdl.handle.net/10033/621337
DOI:
10.1007/s00018-018-2784-1
PubMed ID:
29502308
Type:
Article
Language:
en
ISSN:
1420-9071
Appears in Collections:
Publications of Scientific Director (GFW)

Full metadata record

DC FieldValue Language
dc.contributor.authorNonnenmacher, Yannicen
dc.contributor.authorHiller, Karstenen
dc.date.accessioned2018-04-06T09:36:46Z-
dc.date.available2018-04-06T09:36:46Z-
dc.date.issued2018-03-03-
dc.identifier.citationBiochemistry of proinflammatory macrophage activation. 2018 Cell. Mol. Life Sci.en
dc.identifier.issn1420-9071-
dc.identifier.pmid29502308-
dc.identifier.doi10.1007/s00018-018-2784-1-
dc.identifier.urihttp://hdl.handle.net/10033/621337-
dc.description.abstractIn the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleBiochemistry of proinflammatory macrophage activation.en
dc.typeArticleen
dc.contributor.departmentHelmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.en
dc.identifier.journalCellular and molecular life sciences : CMLSen

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