2.50
Hdl Handle:
http://hdl.handle.net/10033/621348
Title:
Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.
Authors:
Vendelova, Emilia; Ashour, Diyaaeldin; Blank, Patrick; Erhard, Florian; Saliba, Antoine-Emmanuel; Kalinke, Ulrich ( 0000-0003-0503-9564 ) ; Lutz, Manfred B
Abstract:
Dendritic cells (DCs) are key directors of tolerogenic and immunogenic immune responses. During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases or other hyperreactivities. Different DC subsets contribute to pathogen recognition by expression of different subsets of pattern recognition receptors, including Toll-like receptors or C-type lectins. In addition to the triggering of immune responses in infected hosts, most pathogens have evolved mechanisms for evasion of targeted responses. One such strategy is characterized by adopting the host's T cell tolerance mechanisms. Understanding these tolerogenic mechanisms is of utmost importance for therapeutic approaches to treat immune pathologies, tumors and infections. Transcriptional profiling has developed into a potent tool for DC subset identification. Here, we review and compile pathogen-induced tolerogenic transcriptional signatures from mRNA profiling data of currently available bacterial- or helminth-induced transcriptional signatures. We compare them with signatures of tolerogenic steady-state DC subtypes to identify common and divergent strategies of pathogen induced immune evasion. Candidate molecules are discussed in detail. Our analysis provides further insights into tolerogenic DC signatures and their exploitation by different pathogens.
Affiliation:
TWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Citation:
Tolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells. 2018, 9:333 Front Immunol
Journal:
Frontiers in immunology
Issue Date:
2018
URI:
http://hdl.handle.net/10033/621348
DOI:
10.3389/fimmu.2018.00333
PubMed ID:
29541071
Type:
Article
Language:
en
ISSN:
1664-3224
Appears in Collections:
publications of the department of experimental infection research ([TC] EXPI)

Full metadata record

DC FieldValue Language
dc.contributor.authorVendelova, Emiliaen
dc.contributor.authorAshour, Diyaaeldinen
dc.contributor.authorBlank, Patricken
dc.contributor.authorErhard, Florianen
dc.contributor.authorSaliba, Antoine-Emmanuelen
dc.contributor.authorKalinke, Ulrichen
dc.contributor.authorLutz, Manfred Ben
dc.date.accessioned2018-04-12T13:31:17Z-
dc.date.available2018-04-12T13:31:17Z-
dc.date.issued2018-
dc.identifier.citationTolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells. 2018, 9:333 Front Immunolen
dc.identifier.issn1664-3224-
dc.identifier.pmid29541071-
dc.identifier.doi10.3389/fimmu.2018.00333-
dc.identifier.urihttp://hdl.handle.net/10033/621348-
dc.description.abstractDendritic cells (DCs) are key directors of tolerogenic and immunogenic immune responses. During the steady state, DCs maintain T cell tolerance to self-antigens by multiple mechanisms including inducing anergy, deletion, and Treg activity. All of these mechanisms help to prevent autoimmune diseases or other hyperreactivities. Different DC subsets contribute to pathogen recognition by expression of different subsets of pattern recognition receptors, including Toll-like receptors or C-type lectins. In addition to the triggering of immune responses in infected hosts, most pathogens have evolved mechanisms for evasion of targeted responses. One such strategy is characterized by adopting the host's T cell tolerance mechanisms. Understanding these tolerogenic mechanisms is of utmost importance for therapeutic approaches to treat immune pathologies, tumors and infections. Transcriptional profiling has developed into a potent tool for DC subset identification. Here, we review and compile pathogen-induced tolerogenic transcriptional signatures from mRNA profiling data of currently available bacterial- or helminth-induced transcriptional signatures. We compare them with signatures of tolerogenic steady-state DC subtypes to identify common and divergent strategies of pathogen induced immune evasion. Candidate molecules are discussed in detail. Our analysis provides further insights into tolerogenic DC signatures and their exploitation by different pathogens.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleTolerogenic Transcriptional Signatures of Steady-State and Pathogen-Induced Dendritic Cells.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalFrontiers in immunologyen

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