Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.

2.50
Hdl Handle:
http://hdl.handle.net/10033/621349
Title:
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
Authors:
Kuhn, Maike; Sühs, Kurt-Wolfram; Akmatov, Manas K; Klawonn, Frank; Wang, Junxi; Skripuletz, Thomas; Kaever, Volkhard; Stangel, Martin; Pessler, Frank
Abstract:
Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.
Affiliation:
TWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
Citation:
Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. 2018, 15 (1):20 J Neuroinflammation
Journal:
Journal of neuroinflammation
Issue Date:
17-Jan-2018
URI:
http://hdl.handle.net/10033/621349
DOI:
10.1186/s12974-017-1041-0
PubMed ID:
29343258
Type:
Article
Language:
en
ISSN:
1742-2094
Appears in Collections:
publications of the research group cellular proteom research (CPRO); publications of the research group biomarker in infection and immunity [[TC] BIOM)

Full metadata record

DC FieldValue Language
dc.contributor.authorKuhn, Maikeen
dc.contributor.authorSühs, Kurt-Wolframen
dc.contributor.authorAkmatov, Manas Ken
dc.contributor.authorKlawonn, Franken
dc.contributor.authorWang, Junxien
dc.contributor.authorSkripuletz, Thomasen
dc.contributor.authorKaever, Volkharden
dc.contributor.authorStangel, Martinen
dc.contributor.authorPessler, Franken
dc.date.accessioned2018-04-12T13:50:11Z-
dc.date.available2018-04-12T13:50:11Z-
dc.date.issued2018-01-17-
dc.identifier.citationMass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. 2018, 15 (1):20 J Neuroinflammationen
dc.identifier.issn1742-2094-
dc.identifier.pmid29343258-
dc.identifier.doi10.1186/s12974-017-1041-0-
dc.identifier.urihttp://hdl.handle.net/10033/621349-
dc.description.abstractVaricella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. We therefore applied a targeted metabolomics screen of CSF to three clinically distinct forms of VZV reactivation and infectious and non-infectious disease controls in order to identify biomarkers for CNS involvement in VZV reactivation.en
dc.language.isoenen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.en
dc.typeArticleen
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.en
dc.identifier.journalJournal of neuroinflammationen

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