Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection.

2.50
Hdl Handle:
http://hdl.handle.net/10033/96275
Title:
Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection.
Authors:
Alberts, Rudi; Srivastava, Barkha; Wu, Haiya; Viegas, Nuno; Geffers, Robert; Klawonn, Frank; Novoselova, Natalia; do Valle, Tania Zaverucha; Panthier, Jean-Jacques; Schughart, Klaus ( 0000-0002-6824-7523 )
Abstract:
Inbred mouse strains exhibit differences in susceptibility to influenza A infections. However, the molecular mechanisms underlying these differences are unknown. Therefore, we infected a highly susceptible mouse strain (DBA/2J) and a resistant strain (C57BL/6J) with influenza A H1N1 (PR8) and performed genome-wide expression analysis. We found genes expressed in lung epithelium that were specifically down-regulated in DBA/2J mice, whereas a cluster of genes on chromosome 3 was only down-regulated in C57BL/6J. In both mouse strains, chemokines, cytokines and interferon-response genes were up-regulated, indicating that the main innate immune defense pathways were activated. However, many immune response genes were up-regulated in DBA/2J much stronger than in C57BL/6J, and several immune response genes were exclusively regulated in DBA/2J. Thus, susceptible DBA/2J mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus.
Affiliation:
Department of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Citation:
Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection. 2010, 12 (4):309-18 Microbes Infect.
Journal:
Microbes and infection / Institut Pasteur
Issue Date:
Apr-2010
URI:
http://hdl.handle.net/10033/96275
DOI:
10.1016/j.micinf.2010.01.008
PubMed ID:
20114087
Type:
Article
Language:
en
ISSN:
1769-714X
Appears in Collections:
publications of the department infection genetics (INFG)

Full metadata record

DC FieldValue Language
dc.contributor.authorAlberts, Rudien
dc.contributor.authorSrivastava, Barkhaen
dc.contributor.authorWu, Haiyaen
dc.contributor.authorViegas, Nunoen
dc.contributor.authorGeffers, Roberten
dc.contributor.authorKlawonn, Franken
dc.contributor.authorNovoselova, Nataliaen
dc.contributor.authordo Valle, Tania Zaveruchaen
dc.contributor.authorPanthier, Jean-Jacquesen
dc.contributor.authorSchughart, Klausen
dc.date.accessioned2010-04-12T09:25:07Zen
dc.date.available2010-04-12T09:25:07Zen
dc.date.issued2010-04en
dc.identifier.citationGene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection. 2010, 12 (4):309-18 Microbes Infect.en
dc.identifier.issn1769-714Xen
dc.identifier.pmid20114087en
dc.identifier.doi10.1016/j.micinf.2010.01.008en
dc.identifier.urihttp://hdl.handle.net/10033/96275en
dc.description.abstractInbred mouse strains exhibit differences in susceptibility to influenza A infections. However, the molecular mechanisms underlying these differences are unknown. Therefore, we infected a highly susceptible mouse strain (DBA/2J) and a resistant strain (C57BL/6J) with influenza A H1N1 (PR8) and performed genome-wide expression analysis. We found genes expressed in lung epithelium that were specifically down-regulated in DBA/2J mice, whereas a cluster of genes on chromosome 3 was only down-regulated in C57BL/6J. In both mouse strains, chemokines, cytokines and interferon-response genes were up-regulated, indicating that the main innate immune defense pathways were activated. However, many immune response genes were up-regulated in DBA/2J much stronger than in C57BL/6J, and several immune response genes were exclusively regulated in DBA/2J. Thus, susceptible DBA/2J mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus.en
dc.language.isoenen
dc.titleGene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection.en
dc.typeArticleen
dc.contributor.departmentDepartment of Infection Genetics, Helmholtz Centre for Infection Research, Braunschweig, Germany.en
dc.identifier.journalMicrobes and infection / Institut Pasteuren

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